Membrane Trafficking & Disease

Defects in membrane trafficking can be disastrous for the cell and for the organism. Diseases as diverse as neurodegeneration, metabolic syndrome, and cancers are known to have at least some causal components related to membrane trafficking. We are particularly interested in studying dysregulated membrane trafficking in cancers. We use biochemical assays, microscopy-based imaging analysis, molecular biology, multiomics, tumor mouse models and clinical data to measure membrane trafficking events and assess how the trafficking machinery drives cancer progression. We work collaboratively and aim to translate our discoveries to address clinical needs.