12 Jul 2024 | News

Markey researcher to investigate key drivers of lung cancer metastasis. [Link]

25 Apr 2024 | Published

Tan X, Wang S, Xiao GY, Wu C, Liu X, Zhou B, Yu J, Duose DY, Xi Y, Wang J, Gupta K, Pataer A, Roth JA, Kim MP, Chen F, Creighton CJ, Russell WK, Kurie JM. Chromosomal 3q amplicon encodes essential regulators of secretory vesicles that drive secretory addiction in cancer. Journal of Clinical Investigation. 2024;134(12):e176355. [Link]

5-10 Apr 2024 | Poster Presentations

Fulp K, Obaleye O , Xiao GY

Epithelial-to-mesenchymal transition-driven secretory program underlies vulnerabilities in lung cancer

AACR Annual Meeting 2024

Obaleye O, Fulp K, Xiao GY

Adaptive membrane trafficking activated by epithelial-to-mesenchymal transition drives lung adenocarcinoma progression

AACR Annual Meeting 2024

5 Jul 2023 | Published

Xiao GY, Tan X, Rodriguez BL, Gibbons DL, Wang S, Wu C, Liu X, Yu J, Vasquez ME, Tran HT, Xu J, Russell WK, Haymaker C, Lee Y, Zhang J, Solis L, Wistuba II, Kurie JM. EMT activates exocytotic Rabs to coordinate invasion and immunosuppression in lung cancer. PNAS. 2023;120 (28): e2220276120. [Link]

* Featured in“Research Highlight” at UT MD Anderson Cancer Center. [Link]

10 Apr 2022 | Invited Talk

Xiao GY.

The EMT activator ZEB1 initiates polarized secretion of pro-tumorigenic effector proteins to drive lung adenocarcinoma progression.

AACR Annual Meeting 2022: “Oncogenic Signaling Drivers” Minisymposium. New Orleans, LA.

08 Apr 2022 | Award

Guan-Yu Xiao was awarded the AACR-June L. Biedler Scholar-in-Training Award from AACR.

03 Nov 2021 | Published

Banerjee P*, Xiao GY*, Tan X, Zheng VJ, Shi L, Rabassedas MNB, Guo HF, Liu X, Yu J, Diao L, Wang J, Russell WK, Roszik J, Creighton CJ, Kurie JM. The EMT activator ZEB1 accelerates endosomal trafficking to establish a polarity axis in lung adenocarcinoma cells. Nature Communication. 2021;12(1): 6354. *Co-first author. [Link]

* Featured in “Research Highlight” at UT MD Anderson Cancer Center. [Link]

15 Sep 2021 | Funded

Guan-Yu Xiao received grant from NIH/NCI (K99CA249048) to study "A pro-metastatic secretory program activated by epithelial-to-mesenchymal transition" (09/15/2021 - 08/31/2026).

29 Apr 2021 | Award

Guan-Yu Xiao was awarded the A. Lavoy Moore Fellowship in Lung Cancer Research from UT MD Anderson Cancer Center.

07 Jul 2020 | Published

Xiao GY and Schmid SL. FCHSD2 controls oncogenic ERK1/2 signaling outcome by regulating endocytic trafficking. PLoS Biology. 2020;18(7): e3000778. [Link]

* Featured in “AACR Travel Grant hall of fame” at Proteintech Group, Inc. [Link]

22 Jun 2020 | Award

Guan-Yu Xiao was awarded the AACR Scholar-in-Training Awards from AACR.

28 Aug 2018 | Published

Xiao GY, Mohanakrishnan A, Schmid SL. ERK1/2-dependent activation of FCHSD2 drives cancer cell-selective regulation of clathrin-mediated endocytosis. PNAS. 2018;115(41): E9570-E9579. [Link]

15 Apr 2018 | Invited Talk

Xiao GY.

Oncogenic signaling pathways differentially regulate clathrin-mediated endocytosis in cancer cells.

AACR Annual Meeting 2018: "Cell Signaling Pathways" Minisymposium. Chicago, IL.

14 Apr 2018 | Award

Guan-Yu Xiao was awarded the AACR-Aflac, Inc. Scholar-in-Training Awards from AACR.